guanosine triphosphate
Also known as GTP, guanosine 5'-triphosphoric acid, H4gtp, 5'-GTP, GTG, Guanosine mono(tetrahydrogen triphosphate) (ester), Guanosine 5'-triphosphorate, ({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
chemical compound
Chemical data
- Formula
- C10H16N5O14P3
- Molecular weight
- 523.18 g/mol
- IUPAC name
- [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
- SMILES
- C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
- InChIKey
- XKMLYUALXHKNFT-UUOKFMHZSA-N
- XLogP
- -5.7
- Polar surface area
- 295 Ų
- H-bond donors
- 8
- H-bond acceptors
- 16
- Formal charge
- 0
via PubChem
Research
25,063 papersArticle
Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It is one of the building blocks needed for the synthesis of RNA during the transcription process. Its structure is similar to that of the guanosine nucleoside, the only difference being that nucleotides like GTP have phosphates on their ribose sugar. GTP has the guanine nucleobase attached to the 1' carbon of the ribose and it has the triphosphate moiety attached to ribose's 5' carbon.
It also has roles as a source of energy and as an activator of substrates in metabolic reactions, similar to the roles of ATP, but it is more specific. It is used as a source of energy for protein synthesis and gluconeogenesis.