Structure via PubChem · Public domain (PubChem)
relebactam
Sign in to saveAlso known as relebactam anhydrous, Relebactam anhydrous
Relebactam is a chemical compound used in combination with antibiotics to improve their efficacy. As a beta-lactamase inhibitor, it blocks the ability of bacteria to break down a beta-lactam antibiotic. In the United States, relebactam is approved for use in the combination imipenem/cilastatin/relebactam (Recarbrio by Merck).
Chemical data
- Formula
- C12H20N4O6S
- Molecular weight
- 348.38 g/mol
- IUPAC name
- [(2S,5R)-7-oxo-2-(piperidin-4-ylcarbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate
- SMILES
- C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)O)C(=O)NC3CCNCC3
- InChIKey
- SMOBCLHAZXOKDQ-ZJUUUORDSA-N
- XLogP
- -3.6
- Polar surface area
- 137 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2019
- Admin. routes
- parenteral
via ChEMBL · EBI
Research
659 papers- Imipenem/Cilastatin/Relebactam: A Review in Gram-Negative Bacterial Infections.Drugs · 2021
- A Randomized, Double-blind, Multicenter Trial Comparing Efficacy and Safety of Imipenem/Cilastatin/Relebactam Versus Piperacillin/Tazobactam in Adults With Hospital-acquired or Ventilator-associated Bacterial Pneumonia (RESTORE-IMI 2 Study).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
- RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
- Imipenem/Cilastatin/Relebactam for Complicated Infections: A Real-World Evidence.Life (Basel, Switzerland) · 2024
- Breaking Through Resistance: A Comparative Review of New Beta-Lactamase Inhibitors (Avibactam, Vaborbactam, Relebactam) Against Multidrug-Resistant Superbugs.Antibiotics (Basel, Switzerland) · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 348.11
Show 5 more facts
- chemical formula
- C₁₂H₂₀N₄O₆S
- canonical SMILES
- C1CC(N2CC1N(C2=O)OS(=O)(=O)O)C(=O)NC3CCNCC3
- subject has role
- beta-lactamase inhibitors
- isomeric SMILES
- C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)O)C(=O)NC3CCNCC3
- Commons category
- Relebactam
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Relebactam is a chemical compound used in combination with antibiotics to improve their efficacy. As a beta-lactamase inhibitor, it blocks the ability of bacteria to break down a beta-lactam antibiotic. In the United States, relebactam is approved for use in the combination imipenem/cilastatin/relebactam (Recarbrio by Merck).
== See also == Avibactam
Excerpted from Wikipedia’s “relebactam” article, available under the CC BY-SA 4.0 licence.