Structure via PubChem · Public domain (PubChem)
ribociclib
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Ribociclib, sold under the brand name Kisqali, is a medication used for the treatment of certain kinds of breast cancer. Ribociclib is a kinase inhibitor. It was developed by Novartis and Astex Pharmaceuticals.
Key facts
- Drug.image
- Ribociclib skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Ribociclib-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Kisqali
- Drug.MedlinePlus
- a617008
- Drug.DailyMedID
- Ribociclib
- Drug.routes_of_administration
- By mouth
- Drug.class
- Antineoplastic, CDK inhibitor
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- EF02
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- Unknown
- Drug.protein_bound
- ~70%
- Drug.metabolism
- Liver (CYP3A4)
via Wikipedia infobox
Chemical data
- Formula
- C23H30N8O
- Molecular weight
- 434.5 g/mol
- IUPAC name
- 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
- SMILES
- CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
- InChIKey
- RHXHGRAEPCAFML-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 91.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2017
- Admin. routes
- oral
- Indications
- lymphoma, melanoma, glioblastoma multiforme, liposarcoma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 434.254
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₃H₃₀N₈O
- canonical SMILES
- CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
- NCI Thesaurus ID
- C95701
- World Health Organisation international non-proprietary name
- ribociclib
- Commons category
- Ribociclib
- subject has role
- protein kinase inhibitors
- medical condition treated
- breast cancer
Sources (5)
via Wikidata · CC0
~10 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- References
{{Infobox drug | image = Ribociclib skeletal.svg | image_class = skin-invert-image | alt = | caption = | image2 = Ribociclib-from-xtal-3D-bs-17.png | image_class2 = bg-transparent
| pronounce = | tradename = Kisqali | Drugs.com = | MedlinePlus = a617008 | DailyMedID = Ribociclib | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = Antineoplastic, CDK inhibitor | ATC_prefix = L01 | ATC_suffix = EF02
Excerpted from Wikipedia’s “ribociclib” article, available under the CC BY-SA 4.0 licence.