Structure via PubChem · Public domain (PubChem)
(RS)-econazole
Sign in to saveAlso known as R-14827, 1-{2,4-dichloro-beta-[(p-chlorobenzyl)oxy]phenethyl}imidazole, (+-)-econazole, econazole
Econazole is an antifungal medication of the imidazole class.
Chemical data
- Formula
- C18H15Cl3N2O
- Molecular weight
- 381.7 g/mol
- IUPAC name
- 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
- SMILES
- C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
- InChIKey
- LEZWWPYKPKIXLL-UHFFFAOYSA-N
- XLogP
- 5.3
- Polar surface area
- 27.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
7 papers- Suppression of TRPV5 Regulates Microglia-Mediated Neuroinflammation Following Status Epilepticus.Glia · 2025
- A chitosan lactate/poloxamer 407-based matrix containing Eudragit RS microparticles for vaginal delivery of econazole: design and in vitro evaluation.Drug development and industrial pharmacy · 2013
- Silver(I) complexes containing antifungal azoles: significant improvement of the anti-Candida potential of the azole drug after its coordination to the silver(I) ion.Dalton transactions (Cambridge, England : 2003) · 2024
- Comparison of the chiral resolution of econazole, miconazole, and sulconazole by HPLC using normal-phase amylose CSPs.Fresenius' journal of analytical chemistry · 2001
- Clinically used antifungal azoles as ligands for gold(III) complexes: the influence of the Au(III) ion on the antimicrobial activity of the complex.Dalton transactions (Cambridge, England : 2003) · 2022
via PubMed
~4 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- Adverse effects
- Synthesis
- Society and culture
- Brand names
- References
- External links
{{Drugbox | Watchedfields = changed | verifiedrevid = 461092342 | drug_name = | INN = | type = | chirality = Racemic mixture | image = Econazole.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = | tradename = Spectazole, Ecostatin, others | Drugs.com = | MedlinePlus = a684049 | licence_CA = | licence_EU = | DailyMedID = Econazole | licence_US = | pregnancy_AU = A | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = Topical | class = | ATCvet = | ATC_prefix = D01 | ATC_suffix = AC03 | ATC_supplemental =
Excerpted from Wikipedia’s “(RS)-econazole” article, available under the CC BY-SA 4.0 licence.