RYR2
Sign in to saveAlso known as ARVC2, ARVD2, RYR-2, RyR, VTSIP, ryanodine receptor 2, VACRDS
protein-coding gene in the species Homo sapiens
Gene data
RYR2- Name
- ryanodine receptor 2
- Type
- protein-coding
- Position
- 237,042,184–237,833,988 (+)
- Aliases
- ARVC2, ARVD2, RYR-2, RyR, VACRDS, VTSIP
- Ensembl
- ENSG00000198626
- RefSeq RNA
- NM_001035.3, XM_006711802.4, XM_006711803.4, XM_006711804.4, XM_006711805.4
- RefSeq protein
- NP_001026.2, XP_006711865.1, XP_006711866.1, XP_006711867.1, XP_006711868.1
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
monoatomic ion channel activityryanodine-sensitive calcium-release channel activityryanodine-sensitive calcium-release channel activityryanodine-sensitive calcium-release channel activityryanodine-sensitive calcium-release channel activitycalcium channel activitycalcium channel activitycalcium ion binding
Pathways
Calcium signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Cardiac muscle contraction - Homo sapiens (human)Adrenergic signaling in cardiomyocytes - Homo sapiens (human)Apelin signaling pathway - Homo sapiens (human)Circadian entrainment - Homo sapiens (human)Insulin secretion - Homo sapiens (human)Oxytocin signaling pathway - Homo sapiens (human)Pancreatic secretion - Homo sapiens (human)Prion disease - Homo sapiens (human)
via MyGene.info
Wikidata facts
- Image
- RYR2 protein.png
Show 5 more facts
- HomoloGene ID
- 37423
- exact match
- identifiers.org/ncbigene/6262
- genomic end
- 237997288
- genomic start
- 237042184
- cytogenetic location
- 1q43
via Wikidata · CC0
Connections
Q180686
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Ensembl genome database project
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