Structure via PubChem · Public domain (PubChem)
(S)-5-OH-DPAT
Sign in to saveAlso known as (S)-6-dipropylaminotetralin-1-ol
5-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with selectivity for the D2 receptor and D3 receptor subtypes. Only the (S)-enantiomer is active as an agonist, with the (R)-enantiomer being a weak antagonist at D2 receptors. Radiolabelled 11C-5-OH-DPAT is used as an agonist radioligand for mapping the distribution and function of D2 and D3 receptors in the brain, and the drug is also being studied in the treatment of Parkinson's disease.
Chemical data
- Formula
- C16H25NO
- Molecular weight
- 247.38 g/mol
- IUPAC name
- (6S)-6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
- SMILES
- CCCN(CCC)[C@H]1CCC2=C(C1)C=CC=C2O
- InChIKey
- MDBWEQVKJDMEMK-AWEZNQCLSA-N
- XLogP
- 4.1
- Polar surface area
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 247.19361442
Show 4 more facts
- chemical formula
- C₁₆H₂₅NO
- isomeric SMILES
- Oc1cccc2c1CC[C@H](N(CCC)CCC)C2
- canonical SMILES
- CCCN(CCC)C1CCC2=C(C1)C=CC=C2O
- Commons category
- 5-OH-DPAT
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
5-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with selectivity for the D2 receptor and D3 receptor subtypes. Only the (S)-enantiomer is active as an agonist, with the (R)-enantiomer being a weak antagonist at D2 receptors. Radiolabelled 11C-5-OH-DPAT is used as an agonist radioligand for mapping the distribution and function of D2 and D3 receptors in the brain, and the drug is also being studied in the treatment of Parkinson's disease.
== See also == 7-OH-DPAT 8-OH-DPAT
Excerpted from Wikipedia’s “(S)-5-OH-DPAT” article, available under the CC BY-SA 4.0 licence.