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GeneQ18033225· pop 5· linked from 488 articles

S1PR4

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Also known as EDG6, LPC1, S1P4, SLP4, sphingosine-1-phosphate receptor 4

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.

Gene data

S1PR4
Name
sphingosine-1-phosphate receptor 4
Type
protein-coding
Position
3,172,346–3,180,332 (+)
Aliases
EDG6, LPC1, S1P4, SLP4
Ensembl
ENSG00000125910
RefSeq RNA
NM_003775.4
RefSeq protein
NP_003766.1

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

FoxO signaling pathway - Homo sapiens (human)Sphingolipid signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)GPCR downstream signallingG alpha (i) signalling eventsLysosphingolipid and LPA receptorsGPCR ligand binding

via MyGene.info

Gene · Ensembl

sphingosine-1-phosphate receptor 4

Symbol
S1PR4
Biotype
Protein coding
Organism
Homo sapiens
Location
19:3,172,346-3,180,332
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
2799
genomic start
3172344
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/8698
genomic end
3180329
chromosome
human chromosome 19
cytogenetic location
19p13.3
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

8 sections
Contents
  • Function
  • Ligands
  • Evolution
  • [[Sequence homology|Paralogues]] to S1PR4 [[Gene]]
  • See also
  • References
  • Further reading
  • External links

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.

== Function ==

Excerpted from Wikipedia’s “S1PR4” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0