Structure via PubChem · Public domain (PubChem)
nilotinib
Sign in to saveAlso known as AMN107, AMN 107, Tasigna®, Nilotinibum
Nilotinib, sold under the brand name Tasigna among others, is an anti-cancer medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome. It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib. It is taken by mouth.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 458285977
- Drug.image
- Nilotinib2DACS.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 300
- Drug.image2
- Nilotinib3Dan.gif
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250
- Drug.tradename
- Tasigna, others
- Drug.MedlinePlus
- a608002
- Drug.DailyMedID
- Nilotinib
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.class
- Antineoplastic
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- EA03
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C28H22F3N7O
- Molecular weight
- 529.5 g/mol
- IUPAC name
- 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
- SMILES
- CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
- InChIKey
- HHZIURLSWUIHRB-UHFFFAOYSA-N
- XLogP
- 4.9
- Polar surface area
- 97.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 529.184
- Has use
- medication
Show 9 more facts
- chemical formula
- C₂₈H₂₂F₃N₇O
- legal status (medicine)
- boxed warning
- canonical SMILES
- CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5
- World Health Organisation international non-proprietary name
- nilotinib
- Commons category
- Nilotinib
- subject has role
- enzyme inhibitor
- medical condition treated
- chronic lymphocytic leukemia
- physically interacts with
- ABL proto-oncogene 1, non-receptor tyrosine kinase
- significant drug interaction
- ketoconazole
Sources (5)
via Wikidata · CC0
~6 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Adverse effects
- Interactions
- Pharmacology
- History
- Society and culture
- Legal status
- Research
- Parkinson's disease
- Other
- References
Nilotinib, sold under the brand name Tasigna among others, is an anti-cancer medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome. It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib. It is taken by mouth.
Common side effects may include low platelets, low white blood cells, anemia, rashes, vomiting, diarrhea, and joint pains. Other serious side effects may include QT prolongation, sudden death, pancreatitis, and liver problems. It is not safe for use during pregnancy. Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer cell.
Excerpted from Wikipedia’s “nilotinib” article, available under the CC BY-SA 4.0 licence.