EntityQ412327· pop 20· linked from 511 articles

nilotinib

Nilotinib, sold under the brand name Tasigna among others, is an anti-cancer medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome. It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib. It is taken by mouth.

Key facts

Drug.Verifiedfields: changed
Drug.verifiedrevid: 458285977
Drug.image: Nilotinib2DACS.svg
Drug.image_class: skin-invert-image
Drug.width: 300
Drug.image2: Nilotinib3Dan.gif
Drug.image_class2: bg-transparent
Drug.width2: 250
Drug.tradename: Tasigna, others
Drug.MedlinePlus: a608002
Drug.DailyMedID: Nilotinib
Drug.pregnancy_AU: D
Drug.routes_of_administration: By mouth
Drug.class: Antineoplastic
Drug.ATC_prefix: L01
Drug.ATC_suffix: EA03
Drug.legal_AU: S4
Drug.legal_CA: Rx-only

via Wikipedia infobox

Article

11 sections

Contents

Medical uses
Adverse effects
Interactions
Pharmacology
History
Society and culture
Legal status
Research
Parkinson's disease
Other
References

Common side effects may include low platelets, low white blood cells, anemia, rashes, vomiting, diarrhea, and joint pains. Other serious side effects may include QT prolongation, sudden death, pancreatitis, and liver problems. It is not safe for use during pregnancy. Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer cell.