SART3
Sign in to saveAlso known as DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), squamous cell carcinoma antigen recognized by T-cells 3, squamous cell carcinoma antigen recognized by T cells 3
Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.
Gene data
SART3- Name
- spliceosome associated factor 3, U4/U6 recycling protein
- Type
- protein-coding
- Position
- 108,522,214–108,561,400 (−)
- Aliases
- DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb)
- Ensembl
- ENSG00000075856
- RefSeq RNA
- NM_001410983.1, NM_014706.4, XM_047429916.1, XM_054373894.1
- RefSeq protein
- NP_001397912.1, NP_055521.1, XP_047285872.1, XP_054229869.1
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
spliceosome associated factor 3, U4/U6 recycling protein
- Symbol
- SART3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:108,522,214-108,561,400
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein SART3 PDB 2do4.png
Show 5 more facts
- HomoloGene ID
- 40977
- genomic end
- 108561400
- exact match
- identifiers.org/ncbigene/9733
- genomic start
- 108522214
- cytogenetic location
- 12q23.3
Sources (4)
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- Further reading
Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.