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GeneQ18037084· pop 7· linked from 822 articles

SATB2

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Also known as GLSS, SATB homeobox 2

Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling. SATB2 shows a restricted mode of expression and is expressed in certain cell nuclei [https://www.proteinatlas.org/ENSG00000119042-SATB2/cell. The SATB2 protein is mainly expressed in the epithelial cells of the colon and rectum, followed by the nuclei of neurons in the brain.

Gene data

SATB2
Name
SATB homeobox 2
Type
protein-coding
Position
199,268,900–199,471,271 (−)
Aliases
C2DELq32q33, DEL2Q32Q33, GLSS
Ensembl
ENSG00000119042
RefSeq RNA
NM_001172509.2, NM_001172517.1, NM_015265.4, NR_134967.2, XM_005246396.4
RefSeq protein
NP_001165980.1, NP_001165988.1, NP_056080.1, XP_005246453.1, XP_047299731.1

This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010].

Gene Ontology

Pathways

Generic Transcription PathwaySUMOylationSUMO E3 ligases SUMOylate target proteinsMetabolism of proteinsSUMOylation of chromatin organization proteinsPost-translational protein modificationRNA Polymerase II TranscriptionGene expression (Transcription)Transcriptional regulation by RUNX2RUNX2 regulates osteoblast differentiation

via MyGene.info

Gene · Ensembl

SATB homeobox 2

Symbol
SATB2
Biotype
Protein coding
Organism
Homo sapiens
Location
2:199,268,900-199,471,271
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~4 min read

Encyclopedic overview

6 sections
Contents
  • Function
  • Structure
  • Clinical significance
  • References
  • Further reading
  • External links

Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling. SATB2 shows a restricted mode of expression and is expressed in certain cell nuclei [https://www.proteinatlas.org/ENSG00000119042-SATB2/cell. The SATB2 protein is mainly expressed in the epithelial cells of the colon and rectum, followed by the nuclei of neurons in the brain.

== Function ==

Excerpted from Wikipedia’s “SATB2” article, available under the CC BY-SA 4.0 licence.

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