SEC61 translocon subunit beta

Also known as SEC61B, protein transport protein Sec61 subunit beta, protein translocation complex beta, Sec61 complex, beta subunit, SEC61 translocon beta subunit, protein transport protein SEC61 beta subunit, Sec61 beta subunit

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.

In the Vinony graph

Within Vinony's link graph, SEC61 translocon subunit beta is referenced by 2 other articles, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 9.

Its subject is documented across 5 Wikipedia language editions.

Protein · UniProt

Protein transport protein Sec61 subunit beta

Gene: SEC61B
Organism: Homo sapiens (Human)
Length: 96 aa
Molecular mass: 9,974 Da
Evidence: 1: Evidence at protein level

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane …

3D-structureAcetylationDirect protein sequencingEndoplasmic reticulumLipoproteinMembranePalmitatePhosphoprotein

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Swiss-Prot (reviewed) · via UniProt

Wikidata facts

Instance of: protein

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found in taxon: Homo sapiens

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Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.

Excerpted from Wikipedia’s “SEC61 translocon subunit beta” article, available under the CC BY-SA 4.0 licence.