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selectin P
Sign in to saveAlso known as GMP-140, platelet activation dependent granule-external membrane protein, CD62 antigen-like family member P, granulocyte membrane protein, SELP, granule membrane protein 140kDa, PADGEM, platelet alpha-granule membrane protein
P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.
Protein · UniProt
P-selectin
- Gene
- SELP
- Organism
- Homo sapiens (Human)
- Length
- 830 aa
- Molecular mass
- 90,820 Da
- Evidence
- 1: Evidence at protein level
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3) (PubMed:37184585)
Swiss-Prot (reviewed) · via UniProt
Research
17,579 papers- P- and E- selectin in venous thrombosis and non-venous pathologies.Journal of thrombosis and haemostasis : JTH · 2022
- P-selectin glycoprotein ligand-1 in T cells.Current opinion in hematology · 2017
- P-selectin/ PSGL-1 inhibitors versus enoxaparin in the resolution of venous thrombosis: a meta-analysis.Thrombosis research · 2010
- P-selectin glycoprotein ligand-1 plays a crucial role in the selective recruitment of leukocytes into the atherosclerotic arterial wall.Trends in cardiovascular medicine · 2009
- The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study.Frontiers in endocrinology · 2023
via PubMed
Clinical Trials
23 registered- NACOMPLETEDThe Effect of Vitamin D Supplementation on HIV-associated Platelet HyperreactivityUniversitas Padjadjaran · NCT02217553
- ACTIVE_NOT_RECRUITINGCorrelation of Artherosclerotic Plaque Volume and Intima Media Thickness With Soluble P-selectinMedical University Innsbruck · NCT01895725
- UNKNOWNLipidomics and Functional Analyses of Platelets in Fabry DiseaseSpital Linth · NCT02649660
- COMPLETEDDevelopmental Endothelial Locus-1, Platelet Count, and Soluble P-selectin in Overweight and Obese SubjectsAswan University Hospital · NCT05864079
- PHASE2COMPLETEDA Study of RO4905417 in Patients Undergoing Coronary Artery Bypass Graft (CABG) SurgeryHoffmann-La Roche · NCT01245634
- PHASE2COMPLETEDStudy to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain CrisesReprixys Pharmaceutical Corporation · NCT01895361
~7 min read
Article
10 sectionsContents
- Gene and regulation
- Structure
- Ligand
- Function
- Role in cancer
- As a drug target
- See also
- References
- Further reading
- External links
P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.
P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets P-selectin is stored in α-granules.