SEMA3F
Sign in to saveAlso known as SEMA-IV, SEMA4, SEMAK, semaphorin 3F
Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.
In the Vinony graph
Vinony's link graph records 4 inbound references to SEMA3F, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 3.
Vinony links it to 5 Wikipedia language editions.
Gene data
SEMA3F- Name
- semaphorin 3F
- Type
- protein-coding
- Position
- 50,155,012–50,189,075 (+)
- Aliases
- SEMA-IV, SEMA4, SEMAK
- Ensembl
- ENSG00000001617
- RefSeq RNA
- NM_001318798.2, NM_001318800.2, NM_004186.5, XM_005265381.5, XM_005265382.5
- RefSeq protein
- NP_001305727.1, NP_001305729.1, NP_004177.3, XP_005265438.1, XP_005265439.1
This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
semaphorin 3F
- Symbol
- SEMA3F
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:50,155,012-50,189,075
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 20885
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6405
- genomic end
- 50226508
- genomic start
- 50192478
- chromosome
- human chromosome 3
- cytogenetic location
- 3p21.31
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.
The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993). Sequence comparisons have grouped the secreted semaphorins into 3 general classes (classes 2, 3 and V), all of which also have an immunoglobulin domain. The semaphorin 3 family, consisting of human semaphorins 3A-G (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins 3A-G, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM]
Excerpted from Wikipedia’s “SEMA3F” article, available under the CC BY-SA 4.0 licence.