semaphorin 4D

Protein · UniProt

Semaphorin-4D

Gene

SEMA4D

Organism

Homo sapiens (Human)

Length

862 aa

Molecular mass

96,150 Da

Evidence

1: Evidence at protein level

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves …

• Semaphorin 4D as a guidance molecule in the immune system.International reviews of immunology · 2021
• Receptor Functions of Semaphorin 4D.Biochemistry. Biokhimiia · 2019
• Semaphorin 4A, 4C, and 4D: Function comparison in the autoimmunity, allergy, and cancer.Gene · 2020
• Osteoblast-osteoclast interactions.Connective tissue research · 2018
• The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis.Frontiers in endocrinology · 2018

via PubMed

• PHASE1/PHASE2COMPLETED
  SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD)Vaccinex Inc. · NCT04381468
• PHASE1COMPLETED
  Evaluation of Safety, Tolerability, and PK of VX15/2503 In Patients With MSVaccinex Inc. · NCT01764737
• PHASE1/PHASE2COMPLETED
  VX15/2503 in Combination With Avelumab in Advanced Non-small Cell Lung CancerVaccinex Inc. · NCT03268057
• PHASE1COMPLETED
  Evaluation of Safety, Tolerability, PK & PD of Intravenous VX15/2503 in Patients With Advanced Solid TumorsVaccinex Inc. · NCT01313065
• UNKNOWN
  Semaphorins 3A and 4D Levels in Heart Failure PatientsBnai Zion Medical Center · NCT02406716

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

via Wikidata · CC0