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ProteinQ907394· pop 11· linked from 844 articles

serum response factor

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Also known as c-fos serum response element-binding transcription factor, SRF, minichromosome maintenance 1 homolog

mammalian protein found in Homo sapiens

Protein · UniProt

Serum response factor

Gene
SRF
Organism
Homo sapiens (Human)
Length
508 aa
Molecular mass
51,593 Da
Evidence
1: Evidence at protein level

SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation an…

3D-structureActivatorDevelopmental proteinDirect protein sequencingDNA-bindingGlycoproteinNucleusPhosphoprotein
View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Research

41,594 papers

via PubMed

Clinical Trials

12 registered

via ClinicalTrials.gov

Wikidata facts

Show 1 more fact
exact match
www.ncbi.nlm.nih.gov/protein/P11831
Sources (5)

via Wikidata · CC0

Available in 11 languages

via Wikidata sitelinks · CC0

Connections

Q180686
Entity
homeobox
Entity
Ensembl genome database project
Entity
Fos proto-oncogene, AP-1 transcription factor subunit
Protein
ELK1
Gene
PDX1
Gene
Wikidata
Entity
chromosome
Entity
public domain
Entity
digital object identifier
Entity
psoriasis
Entity
steroid
Entity
apoptotic process
Entity
bibcode
Entity
cell cycle
Entity
human genome
Entity
Q229883
Entity
base pair
Entity
actin
Entity
skeletal muscle
Entity

Categories

Genes on human chromosome 6Transcription factors