SIGLEC
Sign in to saveAlso known as Sialic acid-binding Ig-like lectin, sialoadhesin, sialic acid binding immunoglobulin-like lectins, sialic acid binding immunoglobulin-like lectin
Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 different mammalian Siglecs, providing an array of different functions based on cell surface receptor-ligand interactions.
Research
6,552 papers- Siglec Ligands.Cells · 2021
- Targeting CD24/Siglec-10 signal pathway for cancer immunotherapy: recent advances and future directions.Cancer immunology, immunotherapy : CII · 2024
- Siglec-mediated regulation of immune cell function in disease.Nature reviews. Immunology · 2014
- Gangliosides as Siglec ligands.Glycoconjugate journal · 2023
- MicroRNA:Siglec crosstalk in cancer progression.Current opinion in chemical biology · 2024
via PubMed
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Article
12 sectionsContents
- History
- Structure
- Ligand binding
- Function
- Signalling
- Phagocytosis and adhesion
- Knock-out studies
- Human/Primate Siglecs
- Mimetics
- Synthesis
- References
- External links
Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 different mammalian Siglecs, providing an array of different functions based on cell surface receptor-ligand interactions.
==History==