sirtuin 1
Sign in to saveAlso known as NAD-dependent protein deacylase sirtuin-1, regulatory protein SIR2 homolog 1, hSIR2, SIRT1, sirtuin type 1, SIR2-like protein 1, NAD-dependent protein deacetylase sirtuin-1
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, sirtuin 1 is referenced by 297 other articles, and connects out to PubMed, Saccharomyces cerevisiae and Ensembl genome database project.
Vinony files it under Aging-related enzymes, Aging-related proteins and EC 3.5.1.
Its subject is documented across 11 Wikipedia language editions.
Protein · UniProt
NAD-dependent protein deacetylase sirtuin-1
- Gene
- SIRT1
- Organism
- Homo sapiens (Human)
- Length
- 747 aa
- Molecular mass
- 81,681 Da
- Evidence
- 1: Evidence at protein level
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:…
Swiss-Prot (reviewed) · via UniProt
Research
12,784 papers- Sirtuin 1 in Host Defense during Infection.Cells · 2022
- Sirtuin 1 as a potential biomarker of undernutrition in the elderly: a narrative review.Critical reviews in food science and nutrition · 2024
- Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging-A Systematic Review.Cells · 2021
- Dual role of sirtuin 1 in inflammatory bowel disease.Immunopharmacology and immunotoxicology · 2020
- Sirtuin 1 and Alzheimer's disease: An up-to-date review.Neuropeptides · 2018
via PubMed
Clinical Trials
7 registered- COMPLETEDSIRT1 Gene Polymorphism With Premature Myocardial Infarction in Young Egyptian PatientsSohag University · NCT05160844
- NACOMPLETEDInfluence of Periodontal Disease Treatment on Serum Levels of Sirtuin 1 and Mannose-binding LectinInCor Heart Institute · NCT03753451
- NACOMPLETEDEffect of Periodontal Treatment on Visfatin, fetuin-a and Sirtuin 1 of Patients With Periodontitis and Type 2 DiabetesOndokuz Mayıs University · NCT05662475
- NACOMPLETEDMetformin and Molecular Aging in PrediabetesDiabetes Foundation, India · NCT07302932
- PHASE2WITHDRAWNMechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic SyndromeUniversity of California, San Francisco · NCT00654667
- NACOMPLETEDAnalgesic and Antioxidant Effects of Melatonin in Pediatric SurgeryUniversity of Parma · NCT06724432
Wikidata facts
- Instance of
- protein
Show 3 more facts
- physically interacts with
- SRT-1720
- cell component
- cytosol
- found in taxon
- Homo sapiens
via Wikidata · CC0