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GeneQ18033987· pop 5· linked from 40 articles

SOCS6

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Also known as CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.

Gene data

SOCS6
Name
suppressor of cytokine signaling 6
Type
protein-coding
Position
70,288,876–70,330,199 (+)
Aliases
CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4
Ensembl
ENSG00000170677
RefSeq RNA
NM_004232.4, NM_016387.1, XM_005266783.5, XM_017026086.2, XM_017026087.2
RefSeq protein
NP_004223.2, XP_005266840.1, XP_016881575.1, XP_016881576.1, XP_047293893.1

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

JAK-STAT signaling pathway - Homo sapiens (human)Prolactin signaling pathway - Homo sapiens (human)Cytokine Signaling in Immune systemSignaling by SCF-KITRegulation of KIT signalingSignal TransductionImmune SystemMetabolism of proteinsPost-translational protein modificationNeddylation

via MyGene.info

Gene · Ensembl

suppressor of cytokine signaling 6

Symbol
SOCS6
Biotype
Protein coding
Organism
Homo sapiens
Location
18:70,288,876-70,330,199
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
found in taxon
Homo sapiens
HomoloGene ID
3120
exact match
identifiers.org/ncbigene/9306
genomic end
70330199
genomic start
70289045
chromosome
human chromosome 18
cytogenetic location
18q22.2
Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections
Contents
  • References
  • Further reading

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI) protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

Excerpted from Wikipedia’s “SOCS6” article, available under the CC BY-SA 4.0 licence.

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