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GeneQ18033763· pop 5· linked from 55 articles

SOCS3

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Also known as ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, suppressor of cytokine signaling 3

Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.

Gene data

SOCS3
Name
suppressor of cytokine signaling 3
Type
protein-coding
Position
78,356,778–78,360,930 (−)
Aliases
ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
Ensembl
ENSG00000184557
RefSeq RNA
NM_001378932.1, NM_001378933.1, NM_003955.5
RefSeq protein
NP_001365861.1, NP_001365862.1, NP_003946.3

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Ubiquitin mediated proteolysis - Homo sapiens (human)Osteoclast differentiation - Homo sapiens (human)JAK-STAT signaling pathway - Homo sapiens (human)TNF signaling pathway - Homo sapiens (human)Insulin signaling pathway - Homo sapiens (human)Prolactin signaling pathway - Homo sapiens (human)Adipocytokine signaling pathway - Homo sapiens (human)Type II diabetes mellitus - Homo sapiens (human)Insulin resistance - Homo sapiens (human)Non-alcoholic fatty liver disease - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

suppressor of cytokine signaling 3

Symbol
SOCS3
Biotype
Protein coding
Organism
Homo sapiens
Location
17:78,356,778-78,360,930
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Protein SOCS3 PDB 2bbu.png
Show 8 more facts
HomoloGene ID
2941
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/9021
genomic end
76356158
genomic start
76352864
expressed in
lactiferous duct
chromosome
human chromosome 17
cytogenetic location
17q25.3
Sources (5)

via Wikidata · CC0

~2 min read

Encyclopedic overview

6 sections
Contents
  • Function
  • Interactions
  • Regulation
  • See also
  • References
  • Further reading

Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.

SOCS3 is a conserved gene, found in across the animal kingdom, including Drosophila, chickens, and crocodiles.

Excerpted from Wikipedia’s “SOCS3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0