IRF3
Sign in to saveAlso known as entrez:3661, IIAE7, interferon regulatory factor 3
Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.
Gene data
IRF3- Name
- interferon regulatory factor 3
- Type
- protein-coding
- Position
- 49,659,569–49,665,864 (−)
- Aliases
- IIAE7
- Ensembl
- ENSG00000126456
- RefSeq RNA
- NM_001197122.2, NM_001197123.2, NM_001197124.2, NM_001197125.2, NM_001197126.2
- RefSeq protein
- NP_001184051.1, NP_001184052.1, NP_001184053.1, NP_001184054.1, NP_001184055.1
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
interferon regulatory factor 3
- Symbol
- IRF3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:49,659,569-49,665,864
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.
== Function ==
Excerpted from Wikipedia’s “IRF3” article, available under the CC BY-SA 4.0 licence.