SOST
Sign in to saveAlso known as CDD, SOST1, VBCH, DAND6, sclerostin, Sclerostin
Sclerostin is a protein that in humans is encoded by the SOST gene. It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced primarily by the osteocyte but is also expressed in other tissues, and has anti-anabolic effects on bone formation.
Key facts
- Protein family.Symbol
- Sclerostin
- Protein family.Name
- Sclerostin
- Protein family.Pfam
- PF05463
- Protein family.InterPro
- IPR008835
via Wikipedia infobox
Gene data
SOST- Name
- sclerostin
- Type
- protein-coding
- Position
- 43,753,738–43,758,791 (−)
- Aliases
- CDD, DAND6, SOST1, VBCH
- Ensembl
- ENSG00000167941
- RefSeq RNA
- NM_025237.3
- RefSeq protein
- NP_079513.1
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sclerostin
- Symbol
- SOST
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:43,753,738-43,758,791
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 2KD3.png
Show 8 more facts
- HomoloGene ID
- 11542
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/50964
- chromosome
- human chromosome 17
- genomic start
- 43753738
- genomic end
- 43758791
- cytogenetic location
- 17q21.31
- Commons category
- Sclerostin
via Wikidata · CC0
~4 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Function
- Clinical significance
- Sclerostin antibody
- References
- Further reading
- External links
Sclerostin is a protein that in humans is encoded by the SOST gene. It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced primarily by the osteocyte but is also expressed in other tissues, and has anti-anabolic effects on bone formation.
== Structure ==
Excerpted from Wikipedia’s “SOST” article, available under the CC BY-SA 4.0 licence.