STAT4

Name

signal transducer and activator of transcription 4

Type

protein-coding

Position

191,029,570–191,178,435 (−)

Aliases

DPMC, SLEB11

Ensembl

ENSG00000138378

RefSeq RNA

NM_001243835.2, NM_003151.4, XM_006712719.4, XM_047445603.1, XM_047445604.1

RefSeq protein

NP_001230764.1, NP_003142.1, XP_006712782.1, XP_047301559.1, XP_047301560.1

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].

via MyGene.info

Gene · Ensembl

signal transducer and activator of transcription 4

Symbol

STAT4

Biotype

Protein coding

Organism

Homo sapiens

Location

2:191,029,570-191,178,435

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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