TAS2R46
Sign in to saveAlso known as T2R46, T2R54, taste 2 receptor member 46
Taste receptor type 2 member 46 is a protein that in humans is encoded by the TAS2R46 gene.
Gene data
TAS2R46- Name
- taste 2 receptor member 46
- Type
- protein-coding
- Position
- 11,061,365–11,062,294 (−)
- Aliases
- T2R46, T2R54
- Ensembl
- ENSG00000278111
- RefSeq RNA
- NM_001426846.1, NM_176887.2
- RefSeq protein
- NP_001413775.1, NP_795368.2
TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
taste 2 receptor member 46
- Symbol
- TAS2R46
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR12_3_CTG2:262,229-263,158
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~4 min read
Encyclopedic overview
9 sectionsContents
- Gene
- Structure
- Tissue distribution
- Ligands
- Clinical significance
- SNPs
- Known mutations
- References
- Further reading
Taste receptor type 2 member 46 is a protein that in humans is encoded by the TAS2R46 gene.
Taste receptors for bitter substances (T2Rs/TAS2Rs) belong to the family of G-protein coupled receptors and are related to class A-like GPCRs. There are 25 known T2Rs in humans responsible for bitter taste perception.
Excerpted from Wikipedia’s “TAS2R46” article, available under the CC BY-SA 4.0 licence.