teprotumumab
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Teprotumumab, sold under the brand name Tepezza, is a medication used to treat thyroid eye disease (Graves' eye disease), a rare condition where the muscles and fatty tissues behind the eye become inflamed, causing the eyes to bulge outwards. It is a human monoclonal antibody developed by Genmab and Roche for tumor treatment but was later developed by River Vision Development Corporation and Horizon Therapeutics to be used for ophthalmic uses. It binds to IGF-1R.
In the Vinony graph
Vinony's link graph records 681 inbound references to teprotumumab, and connects out to IGF1R, human and medication.
It is catalogued under topics including Chemicals that do not have a ChemSpider ID assigned, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.
Vinony links it to 6 Wikipedia language editions.
Research
437 papers- Teprotumumab for the Treatment of Active Thyroid Eye Disease.The New England journal of medicine · 2020
- Teprotumumab.2006
- Teprotumumab: A Review in Thyroid Eye Disease.Drugs · 2022
- Teprotumumab Efficacy, Safety, and Durability in Longer-Duration Thyroid Eye Disease and Re-treatment: OPTIC-X Study.Ophthalmology · 2022
- Teprotumumab.2012
via PubMed
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Encyclopedic overview
5 sectionsContents
- Medical use
- History
- Society and culture
- Legal status
- References
Teprotumumab, sold under the brand name Tepezza, is a medication used to treat thyroid eye disease (Graves' eye disease), a rare condition where the muscles and fatty tissues behind the eye become inflamed, causing the eyes to bulge outwards. It is a human monoclonal antibody developed by Genmab and Roche for tumor treatment but was later developed by River Vision Development Corporation and Horizon Therapeutics to be used for ophthalmic uses. It binds to IGF-1R.
The most common side effects are muscle spasm, nausea, hair loss, diarrhea, fatigue, high blood sugar, hearing loss, dry skin, altered sense of taste, and headache. Teprotumumab should not be used if pregnant.
Excerpted from Wikipedia’s “teprotumumab” article, available under the CC BY-SA 4.0 licence.