Structure via PubChem · Public domain (PubChem)
tetroxoprim
Sign in to saveTetroxoprim (INN) is a derivative of trimethoprim. It was first described in 1979.
Chemical data
- Formula
- C16H22N4O4
- Molecular weight
- 334.37 g/mol
- IUPAC name
- 5-[[3,5-dimethoxy-4-(2-methoxyethoxy)phenyl]methyl]pyrimidine-2,4-diamine
- SMILES
- COCCOC1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC
- InChIKey
- WSWJIZXMAUYHOE-UHFFFAOYSA-N
- XLogP
- 0.6
- Polar surface area
- 115 Ų
- H-bond donors
- 2
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
76 papers- Tetroxoprim--a new inhibitor of bacterial dihydrofolate reductase.The Journal of antimicrobial chemotherapy · 1979
- [A sulfadiazine-tetroxoprim combination (co-tetroxazine) in the treatment of the acute exacerbation of chronic bronchitis].Minerva medica · 1988
- Pharmacokinetics of trimethoprim and tetroxoprim. A review.Antibiotics and chemotherapy · 1982
- Bioequivalency studies on tablet formulation of tetroxoprim and sulphadiazine.Journal of clinical pharmacy and therapeutics · 1992
- HPLC determination of tetroxoprim and sulphadiazine in pharmaceutical dosage forms and in biological fluids.Journal of pharmaceutical and biomedical analysis · 1989
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 334.164
Show 3 more facts
- chemical formula
- C₁₆H₂₂N₄O₄
- canonical SMILES
- COCCOC1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC
- Commons category
- Tetroxoprim
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Tetroxoprim (INN) is a derivative of trimethoprim. It was first described in 1979.
Tetroxoprim is used often in combination with sulfadiazine (co-tetroxazine) for treating bacterial infections, with brand names including Biroxin and Tibirox.
Excerpted from Wikipedia’s “tetroxoprim” article, available under the CC BY-SA 4.0 licence.