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GeneQ18031961· pop 5· linked from 6 articles

TFDP2

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Also known as DP2, transcription factor Dp-2

Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in the regulation of the cell cycle. ==References==

In the Vinony graph

Vinony's link graph records 6 inbound references to TFDP2, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 3.

Vinony links it to 5 Wikipedia language editions.

Gene data

TFDP2

Name: transcription factor Dp-2
Type: protein-coding
Position: 141,944,428–142,149,598 (−)
Aliases: DP2
Ensembl: ENSG00000114126
RefSeq RNA: NM_001178138.2, NM_001178139.2, NM_001178140.2, NM_001178141.2, NM_001178142.2
RefSeq protein: NP_001171609.1, NP_001171610.1, NP_001171611.1, NP_001171612.1, NP_001171613.1

The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of gene expression negative regulation of DNA-templated transcription negative regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II regulation of cell cycle

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific protein binding transcription factor binding protein domain specific binding

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex DRM complex

Pathways

Cell cycle - Homo sapiens (human)Apoptosis Intrinsic Pathway for Apoptosis Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 E2F mediated regulation of DNA replication Activation of BH3-only proteins Developmental Biology Developmental Biology Transcription of E2F targets under negative control by DREAM complex

via MyGene.info

Gene · Ensembl

transcription factor Dp-2

Symbol: TFDP2
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:141,944,428-142,149,598
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein TFDP2 PDB 1cf7.png

Show 8 more facts

HomoloGene ID: 4578
genetic association: kidney disease
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7029
genomic end: 141868386
genomic start: 141663277
chromosome: human chromosome 3
cytogenetic location: 3q23

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in the regulation of the cell cycle. ==References==

==Further reading==

Excerpted from Wikipedia’s “TFDP2” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 3