Structure via PubChem · Public domain (PubChem)
thioproperazine
Sign in to saveAlso known as N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide, 2-dimethylsulfamido-[10-(3-1-methylpiperazinyl-4)propyl]-phenothiazine
Thioproperazine, sold under the brand name Majeptil, is a typical antipsychotic of the phenothiazine group which is used as a tranquilizer, antiemetic, sedative, and in the treatment of schizophrenia and manic phase of bipolar disorder. Majeptil is available in 10 mg tablets.
Key facts
- Drug.drug_name
- Thioproperazine
- Drug.image
- Thioproperazine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 240
- Drug.alt
- Chemical structure of Thioproperazine
- Drug.tradename
- Majeptil
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- AB08
- Drug.legal_BR
- C1
- Drug.CAS_number
- 316-81-4
- Drug.PubChem
- 9429
- Drug.DrugBank
- DB01622
- Drug.ChemSpiderID
- 9058
- Drug.UNII
- YJ050AQ56X
- Drug.KEGG
- D08585
- Drug.ChEBI
- 59120
- Drug.ChEMBL
- 609109
- Drug.IUPAC_name
- N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine-2-carboxamide
via Wikipedia infobox
Chemical data
- Formula
- C22H30N4O2S2
- Molecular weight
- 446.6 g/mol
- IUPAC name
- N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
- SMILES
- CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
- InChIKey
- VZYCZNZBPPHOFY-UHFFFAOYSA-N
- XLogP
- 3.7
- Polar surface area
- 80.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- psychosis
via ChEMBL · EBI
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- 446.181018
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₂H₃₀N₄O₂S₂
- Commons category
- Thioproperazine
- defined daily dose
- 20
- canonical SMILES
- CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
- World Health Organisation international non-proprietary name
- thioproperazine
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Side effects
- Drug interactions
- Synthesis
- References
Thioproperazine, sold under the brand name Majeptil, is a typical antipsychotic of the phenothiazine group which is used as a tranquilizer, antiemetic, sedative, and in the treatment of schizophrenia and manic phase of bipolar disorder. Majeptil is available in 10 mg tablets.
== Side effects == Common Extrapyramidal symptoms Amenorrhea Decreased sexual interest and/or function Swelling of breasts and milk production in males and females Difficulty sleeping Constipation Reduced amount of urine Dizziness Drowsiness Dry mouth Nausea Headache Weight changes
Excerpted from Wikipedia’s “thioproperazine” article, available under the CC BY-SA 4.0 licence.