thromboplastin
Sign in to saveThromboplastin (TPL) is derived from cell membranes and is a mixture of both phospholipids and tissue factor, neither of which are enzymes. Thromboplastin acts on and accelerates the activity of Factor Xa, also known as thrombokinase, aiding blood coagulation through catalyzing the conversion of prothrombin to thrombin. Thromboplastin is found in brain, lung, and other tissues and especially in blood platelets.
Research
29,171 papers- Thromboplastin calibration.Thrombosis and haemostasis · 1977
- Thromboplastin generation.Lancet (London, England) · 1978
- Synthesis of thromboplastin (tissue factor) by endothelial cells.Haemostasis · 1988
- Thromboplastin calibration revisited to look for possible revision of the World Health Organization recommendations.Journal of thrombosis and haemostasis : JTH · 2023
- Thromboplastin--sensitivity, precision and other characteristics.Clinical and laboratory haematology · 1988
via PubMed
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Encyclopedic overview
4 sectionsContents
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Thromboplastin (TPL) is derived from cell membranes and is a mixture of both phospholipids and tissue factor, neither of which are enzymes. Thromboplastin acts on and accelerates the activity of Factor Xa, also known as thrombokinase, aiding blood coagulation through catalyzing the conversion of prothrombin to thrombin. Thromboplastin is found in brain, lung, and other tissues and especially in blood platelets.
Thromboplastin is sometimes used as a synonym for the protein tissue factor (with its official name "Coagulation factor III [thromboplastin, tissue factor]"). Historically, thromboplastin was a lab reagent, usually derived from placental sources, used to assay prothrombin times (PT).
Excerpted from Wikipedia’s “thromboplastin” article, available under the CC BY-SA 4.0 licence.