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GeneQ18040221· pop 6· linked from 431 articles

TNFRSF12A

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Also known as CD266, FN14, TWEAKR, tumor necrosis factor receptor superfamily member 12A, TNF receptor superfamily member 12A

Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.

Gene data

TNFRSF12A
Name
TNF receptor superfamily member 12A
Type
protein-coding
Position
3,018,445–3,022,385 (+)
Aliases
CD266, FN14, TWEAKR
Ensembl
ENSG00000006327
RefSeq RNA
NM_016639.3
RefSeq protein
NP_057723.1

Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular function

protein binding

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)Cytokine Signaling in Immune systemImmune SystemTNFR2 non-canonical NF-kB pathwayTNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayTNF related weak inducer of apoptosis (TWEAK) Signaling Pathway

via MyGene.info

Gene · Ensembl

TNF receptor superfamily member 12A

Symbol
TNFRSF12A
Biotype
Protein coding
Organism
Homo sapiens
Location
16:3,018,445-3,022,385
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~5 min read

Encyclopedic overview

6 sections
Contents
  • Structure
  • Discovery
  • Therapeutic Strategies
  • Interactions
  • References
  • Further reading

Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.

Other names used when talking about  TNFRSF12A are fibroblast growth factor-inducible immediate-early response protein 14 (FN14). TNFRSF12A is a unique member of the Tumor Necrosis Factor Receptor superfamily. TNFRSF12A is the smallest member of the Tumor Necrosis Factor Receptor superfamily and the gene expression is highly regulated in a live organism and a petri dish. TNFRSF12A is the receptor for the TWEAK which is its ligand. Many other members of the Tumor necrosis factor superfamily can bind to other ligands but this receptor can only bind to TNFRSF12. TNFRSF12A is found in many human tissues, including the heart, placenta, lung, skeletal muscle, kidney, and pancreas. It is involved in several biological processes, such as inflammatory reactions, angiogenesis, cell proliferation, and cell death.

Excerpted from Wikipedia’s “TNFRSF12A” article, available under the CC BY-SA 4.0 licence.

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