Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.
Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.
Other names used when talking about TNFRSF12A are fibroblast growth factor-inducible immediate-early response protein 14 (FN14). TNFRSF12A is a unique member of the Tumor Necrosis Factor Receptor superfamily. TNFRSF12A is the smallest member of the Tumor Necrosis Factor Receptor superfamily and the gene expression is highly regulated in a live organism and a petri dish. TNFRSF12A is the receptor for the TWEAK which is its ligand. Many other members of the Tumor necrosis factor superfamily can bind to other ligands but this receptor can only bind to TNFRSF12. TNFRSF12A is found in many human tissues, including the heart, placenta, lung, skeletal muscle, kidney, and pancreas. It is involved in several biological processes, such as inflammatory reactions, angiogenesis, cell proliferation, and cell death.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).