Thromboxane A synthase 1
Sign in to saveAlso known as thromboxane A synthase 1 (platelet), cytochrome P450, family 5, subfamily A, polypeptide 1, platelet, cytochrome P450, subfamily V, thromboxane-A synthase, TXA synthase, TBXAS1, cytochrome P450 5A1
mammalian protein found in Homo sapiens
Protein · UniProt
Thromboxane-A synthase
- Gene
- TBXAS1
- Organism
- Homo sapiens (Human)
- Length
- 533 aa
- Molecular mass
- 60,518 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, PubMed:24009185, PubMed:8436233, PubMed:9873013). Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:22735388, PubMed:9873013). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,…
Swiss-Prot (reviewed) · via UniProt
Research
1,483 papers- Thromboxane A synthase 1 gene expression and promotor haplotypes are associated with risk of large artery-atherosclerosis stroke in Iranian population.Journal of cellular biochemistry · 2019
- Thromboxane A synthase enhances blood flow recovery from hindlimb ischemia.The Journal of surgical research · 2016
- Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients.Pharmacogenomics · 2011
- Thromboxane A(2) synthase inhibitor enhanced antithrombotic efficacy of GPIIb-IIIa receptor antagonist without increasing bleeding.European journal of pharmacology · 2001
- Dazoxiben.Lancet (London, England) · 1983
via PubMed