Structure via PubChem · Public domain (PubChem)
terutroban
Sign in to saveAlso known as S 18886, S18886, triplion
Terutroban is an antiplatelet agent developed by Servier Laboratories. It is a selective thromboxane prostanoid (TP) antagonist and is an orally active drug in clinical development for the secondary prevention of acute thrombotic complications.
In the Vinony graph
Vinony's link graph records 313 inbound references to terutroban, and connects out to hirudin, coagulation factor X and platelet aggregation inhibitors.
It sits within the topics 2-Aminotetralins, 4-Chlorophenyl compounds and Antiplatelet drugs.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C20H22ClNO4S
- Molecular weight
- 407.9 g/mol
- IUPAC name
- 3-[(6R)-6-[(4-chlorophenyl)sulfonylamino]-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]propanoic acid
- SMILES
- CC1=C(C2=C(C[C@@H](CC2)NS(=O)(=O)C3=CC=C(C=C3)Cl)C=C1)CCC(=O)O
- InChIKey
- HWEOXFSBSQIWSY-MRXNPFEDSA-N
- XLogP
- 4.1
- Polar surface area
- 91.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 407.095807
Show 4 more facts
- chemical formula
- C₂₀H₂₂ClNO₄S
- isomeric SMILES
- CC1=C(C2=C(C[C@@H](CC2)NS(=O)(=O)C3=CC=C(C=C3)Cl)C=C1)CCC(=O)O
- canonical SMILES
- CC1=C(C2=C(CC(CC2)NS(=O)(=O)C3=CC=C(C=C3)Cl)C=C1)CCC(=O)O
- physically interacts with
- Thromboxane A2 receptor
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
2 sectionsContents
- Method of action
- References
{{drugbox | Verifiedfields = changed | Watchedfields = changed | UNII_Ref = | UNII = A6WX9391D8 | verifiedrevid = 407704475 | IUPAC_name = 3-((6R)-6-{[(4-Chlorophenyl)sulfonyl]amido}-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]propanoic acid | image = Terutroban acid skeletal.svg | image_class = skin-invert-image | CAS_number_Ref = | CAS_number = 165538-40-9 | CAS_supplemental = (sodium salt) | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | PubChem = 9938840 | ChemSpiderID_Ref = | ChemSpiderID = 8114465 | StdInChI_Ref = | StdInChI = 1S/C20H22ClNO4S/c1-13-2-3-14-12-16(6-9-19(14)18(13)10-11-20(23)24)22-27(25,26)17-7-4-15(21)5-8-17/h2-5,7-8,16,22H,6,9-12H2,1H3,(H,23,24)/t16-/m1/s1 | StdInChIKey_Ref = | StdInChIKey = HWEOXFSBSQIWSY-MRXNPFEDSA-N | DrugBank_Ref = | DrugBank = | chemical_formula = | C=20 | H=22 | Cl=1 | N=1 | O=4 | S=1 | smiles = CC1=C(C2=C(CC(CC2)NS(=O)(=O)C3=CC=C(C=C3)Cl)C=C1)CCC(=O)O | bioavailability = | protein_bound = | metabolism = | elimination_half-life = 6–10 hours | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Investigational | routes_of_administration = Oral }}
Terutroban is an antiplatelet agent developed by Servier Laboratories. It is a selective thromboxane prostanoid (TP) antagonist and is an orally active drug in clinical development for the secondary prevention of acute thrombotic complications.
Excerpted from Wikipedia’s “terutroban” article, available under the CC BY-SA 4.0 licence.