File:Thyroxine2.svg · Wikimedia Commons · See Wikimedia Commons
甲状腺素
Sign in to saveAlso known as DL-thyroxine
Thyroxine, also known as T4, is a hormone produced by the thyroid gland. It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T3). Thyroxine and its active metabolites are essential for regulating metabolic rate, supporting heart and muscle function, promoting brain development, and maintaining bone health.
OverviewAI-generated
Thyroxine is a chemical compound with the formula C₁₅H₁₁I₄NO₄. Its IUPAC name is 2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate. The molecule has a mass of 776.686699832 and a weight of 776.87. It possesses a charge of 0, an xlogp of 3, and a topological polar surface area of 97.2. The structure includes two hydrogen bond donors and four hydrogen bond acceptors.
The compound is associated with a PubMed query count of 66778. It is referenced by 370 other encyclopedia articles.
Synthesized by Vinony from 17 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Chemical data
- Formula
- C15H11I4NO4
- Molecular weight
- 776.87 g/mol
- IUPAC name
- 2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate
- SMILES
- C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)[O-])[NH3+]
- InChIKey
- XUIIKFGFIJCVMT-UHFFFAOYSA-N
- XLogP
- 3
- Polar surface area
- 97.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
66,778 papers- Thyroxine's evolutionary roots.Perspectives in biology and medicine · 1997
- A short review on the role of thyroxine in fast wound healing and tissue regeneration.Tissue & cell · 2023
- DIETARY thyroxine and hypothyroidism.Nutrition reviews · 1953
- Recent developments with thyroxine.The Pharmaceutical journal · 1949
- A bivariate reference interval for TSH and free thyroxine.Scandinavian journal of clinical and laboratory investigation · 2024
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 776.686699832
Show 3 more facts
- canonical SMILES
- O=C(O)C(N)CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1
- chemical formula
- C₁₅H₁₁I₄NO₄
- Commons category
- Thyroxine
Sources (5)
via Wikidata · CC0
Article · 中文
甲状腺素（Thyroxine）全名四碘甲腺原氨酸（Tetraiodothyronine，T4），是甲狀腺激素（Thyroid hormones）的一種，由胺基酸和碘組合而成。 甲狀腺素借由影响线粒体及细胞膜的功能、促进DNA转录成RNA，而具促进细胞代谢、增加、刺激组织生长、成熟和分化的功能，並且有助於腸道中葡萄糖的吸收。甲状腺素亦能提高组织对神经系统尤其是交感神经刺激的反应度。 垂体前叶的促甲状腺激素能促进它的分泌。 甲状腺功能亢进时，基础代谢增加造成內分泌旺盛，會有以下生理特徵：頭痛、神經緊張、心跳及呼吸加速、體重減輕、食慾增進、失眠、手抖、多汗、怕熱、疲倦、凸眼、消化不良、腹瀉等問題，需要減少對甲狀腺素主要物質碘的攝取量。 甲状腺功能低下時，會有以下生理特徵：體重上升、怕冷、疲倦、嗜睡、水腫、精神遲鈍等症狀。 食物中碘為主要成分，當缺乏時會造成甲状腺合成减少，引起甲状腺肿胀，俗称“大脖子病”。 东周时，中国已经有了关于甲状腺病的记载（癭瘤），在晋朝时，已经知道了用海藻可以治疗此病。
Abstract from DBpedia / Wikipedia · CC BY-SA