TIAL1

Also known as TCBP, TIAR, TIA1 cytotoxic granule-associated RNA binding protein-like 1, TIA1 cytotoxic granule associated RNA binding protein like 1

Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene.

Gene data

TIAL1

Name: TIA1 cytotoxic granule associated RNA binding protein like 1
Type: protein-coding
Position: 119,571,802–119,597,029 (−)
Aliases: TCBP, TIAR
Ensembl: ENSG00000151923
RefSeq RNA: NM_001033925.2, NM_001323964.2, NM_001323965.2, NM_001323967.2, NM_001323968.2
RefSeq protein: NP_001029097.1, NP_001310893.1, NP_001310894.1, NP_001310896.1, NP_001310897.1

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008].

Pathways

Signal Transduction Signaling by FGFR Signaling by FGFR2 FGFR2 alternative splicing Signaling by Receptor Tyrosine Kinases

via MyGene.info

Gene · Ensembl

TIA1 cytotoxic granule associated RNA binding protein like 1

Symbol: TIAL1
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:119,571,802-119,597,181
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein TIAL1 PDB 1x4g.png

Show 5 more facts

HomoloGene ID: 87796
exact match: identifiers.org/ncbigene/7073
genomic start: 121334199
genomic end: 121356541
cytogenetic location: 10q26.11

Sources (4)

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Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene.

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been shown to function differently with respect to post-transcriptional silencing.