DOT1L

Also known as DOT1, KMT4, DOT1 like histone lysine methyltransferase

DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.

In the Vinony graph

Within Vinony's link graph, DOT1L is referenced by 3 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 19.

Its subject is documented across 5 Wikipedia language editions.

Gene data

DOT1L

Name: DOT1 like histone lysine methyltransferase
Type: protein-coding
Position: 2,163,933–2,232,578 (+)
Aliases: DOT1, KMT4, NDNS
Ensembl: ENSG00000104885
RefSeq RNA: NM_001411141.1, NM_032482.3, XM_011528359.3, XM_011528361.3, XM_047439513.1
RefSeq protein: NP_001398070.1, NP_115871.1, XP_011526661.1, XP_011526663.1, XP_047295469.1

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011].

Pathways

Lysine degradation - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)PKMTs methylate histone lysines Chromatin modifying enzymes Chromatin organization Histone Modifications

via MyGene.info

Gene · Ensembl

DOT1 like histone lysine methyltransferase

Symbol: DOT1L
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:2,163,933-2,232,578
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein DOT1L PDB 1nw3.png

Show 8 more facts

HomoloGene ID: 32779
genetic association: osteoarthritis
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/84444
genomic end: 2232577
genomic start: 2163933
chromosome: human chromosome 19
cytogenetic location: 19p13.3

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.

DOT1L has been reported to play an important role in the processes of mixed-lineage leukemia (MLL)-rearranged leukemias. DOT1L also plays a role in spermatogenesis, where it acts as a transcriptional activator for genes responsible for the histone-to-protamine transition.

Excerpted from Wikipedia’s “DOT1L” article, available under the CC BY-SA 4.0 licence.