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ticagrelor

Structure via PubChem · Public domain (PubChem)

EntityQ420542· pop 22· linked from 375 articles

ticagrelor

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Also known as AR-C126532XX, AZD6140, Brilinta®, Brilique®, AZD 6140, AZD-6140, (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol, (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-D)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y12 receptor. The drug is produced by AstraZeneca. thumb|90 mg tablet of Brilinta

Key facts

Drug.Verifiedfields
changed
Drug.Watchedfields
changed
Drug.verifiedrevid
443228756
Drug.image
Ticagrelor.svg
Drug.image_class
skin-invert-image
Drug.width
200
Drug.image2
Ticagrelor ball-and-stick animation.gif
Drug.tradename
Brilinta, Brilique, others
Drug.MedlinePlus
a611050
Drug.DailyMedID
Ticagrelor
Drug.pregnancy_AU
B1
Drug.routes_of_administration
By mouth
Drug.ATC_prefix
B01
Drug.ATC_suffix
AC24
Drug.legal_AU
S4
Drug.legal_CA
Rx-only
Drug.legal_US
Rx-only
Drug.legal_EU
Rx-only

via Wikipedia infobox

Chemical data

Formula
C23H28F2N6O4S
Molecular weight
522.6 g/mol
IUPAC name
(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
SMILES
CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
InChIKey
OEKWJQXRCDYSHL-FNOIDJSQSA-N
XLogP
2
Polar surface area
164 Ų
H-bond donors
4
H-bond acceptors
12
Formal charge
0

via PubChem

Research

5,022 papers

via PubMed

Wikidata facts

Mass
522.186
Has use
medication
Show 9 more facts
chemical formula
C₂₃H₂₈F₂N₆O₄S
World Health Organisation international non-proprietary name
ticagrelor
canonical SMILES
CCCSC1=NC2=C(C(=N1)NC3CC3C4=CC(=C(C=C4)F)F)N=NN2C5CC(C(C5O)O)OCCO
isomeric SMILES
CCCSC1=NC2=C(C(=N1)N[C@@H]3C[C@H]3C4=CC(=C(C=C4)F)F)N=NN2[C@@H]5C[C@@H]([C@H]([C@H]5O)O)OCCO
Commons category
Ticagrelor
defined daily dose
0.18
medical condition treated
heart disease
significant drug interaction
apixaban
legal status (medicine)
boxed warning
Sources (6)

via Wikidata · CC0

~10 min read

Encyclopedic overview

13 sections
Contents
  • Medical uses
  • Contraindications
  • Adverse effects
  • Interactions
  • Pharmacology
  • Mechanism of action
  • Pharmacokinetics
  • Chemistry
  • Research
  • Comparison with related drugs
  • With clopidogrel
  • With prasugrel
  • References

Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y12 receptor. The drug is produced by AstraZeneca. thumb|90 mg tablet of Brilinta

The most common side effects include dyspnea (difficulty breathing), bleeding and raised uric acid level in the blood.

Excerpted from Wikipedia’s “ticagrelor” article, available under the CC BY-SA 4.0 licence.

Gallery (4)

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via Wikidata sitelinks · CC0