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GeneQ18033362· pop 5· linked from 137 articles

TNFRSF18

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Also known as AITR, CD357, GITR, GITR-D, tumor necrosis factor receptor superfamily member 18, TNF receptor superfamily member 18, ENERGEN

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as glucocorticoid-induced TNFR-related protein (GITR) or CD357. GITR is encoded and tnfrsf18 gene at chromosome 4 in mice. GITR is type I transmembrane protein and is described in 4 different isoforms. GITR human orthologue, also called activation-inducible TNFR family receptor (AITR), is encoded by the TNFRSF18 gene at chromosome 1.

Gene data

TNFRSF18
Name
TNF receptor superfamily member 18
Type
protein-coding
Position
1,203,508–1,206,814 (−)
Aliases
AITR, CD357, ENERGEN, GITR, GITR-D
Ensembl
ENSG00000186891
RefSeq RNA
NM_004195.3, NM_148901.2, NM_148902.2, XM_017002722.3, XM_054339419.1
RefSeq protein
NP_004186.1, NP_683699.1, NP_683700.1, XP_016858211.1, XP_054195394.1

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011].

Gene Ontology

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)Cytokine Signaling in Immune systemImmune SystemGeneric Transcription PathwayTNFR2 non-canonical NF-kB pathwayTNFs bind their physiological receptorsRNA Polymerase II TranscriptionGene expression (Transcription)RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)Transcriptional regulation by RUNX1

via MyGene.info

Gene · Ensembl

TNF receptor superfamily member 18

Symbol
TNFRSF18
Biotype
Protein coding
Organism
Homo sapiens
Location
1:1,203,508-1,206,814
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~5 min read

Encyclopedic overview

11 sections
Contents
  • Tissue distribution
  • Structure
  • Function
  • AITR
  • GITR
  • Signaling
  • Clinical significance
  • Atherosclerosis
  • Animal models
  • References
  • Further reading

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as glucocorticoid-induced TNFR-related protein (GITR) or CD357. GITR is encoded and tnfrsf18 gene at chromosome 4 in mice. GITR is type I transmembrane protein and is described in 4 different isoforms. GITR human orthologue, also called activation-inducible TNFR family receptor (AITR), is encoded by the TNFRSF18 gene at chromosome 1.

== Tissue distribution ==

Excerpted from Wikipedia’s “TNFRSF18” article, available under the CC BY-SA 4.0 licence.

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