TOB1

Also known as APRO6, PIG49, TOB, TROB, TROB1, transducer of ERBB2, 1, APRO5

gen de la especie Homo sapiens

In the Vinony graph

Within Vinony's link graph, TOB1 is referenced by 7 other articles, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 17.

Its subject is documented across 7 Wikipedia language editions.

Gene data

TOB1

Name: transducer of ERBB2, 1
Type: protein-coding
Position: 50,861,311–50,867,978 (−)
Aliases: APRO5, APRO6, PIG49, TOB, TROB, TROB1
Ensembl: ENSG00000141232
RefSeq RNA: NM_001243877.2, NM_001243885.2, NM_005749.4
RefSeq protein: NP_001230806.1, NP_001230814.1, NP_005740.1

This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

negative regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of cell population proliferation regulation of gene expression negative regulation of translation negative regulation of DNA-templated transcription negative regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Molecular function

transcription corepressor activity transcription corepressor activity protein binding receptor tyrosine kinase binding SMAD binding

Cellular component

nucleus nucleus cytoplasm cytoplasm CCR4-NOT complex

Pathways

RNA degradation - Homo sapiens (human)Bone morphogenic protein (BMP) signaling and regulation Exercise-induced Circadian Regulation

via MyGene.info

Gene · Ensembl

transducer of ERBB2, 1

Symbol: TOB1
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:50,861,311-50,867,978
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: PDB 2z15 EBI.png

Show 7 more facts

HomoloGene ID: 31334
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10140
genomic end: 48945339
genomic start: 48939584
chromosome: human chromosome 17
cytogenetic location: 17q21.33

Sources (4)

via Wikidata · CC0

Article · Español

TOB1 es una proteína codificada en humanos por el gen tob1. TOB1 pertenece a la familia de proteínas anti-proliferativas tob/btg1, cuyos miembros se caracterizan por poseer la capacidad de regular la proliferación celular. Cuando TOB1 es expresado exógenamente, suprime el crecimiento celular en tejidos en cultivo. La proteína sufre fosforilación por una serina/treonina quinasa S6 ribosomal. La interacción de esta proteína con el producto del oncogén de la leucemia viral eritroblástica v-erb-b2 interfiere con la supresión del crecimiento. TOB1 inhibe la proliferación de linfocitos T y la transcripción de citoquinas y ciclinas. La proteína interacciona con SMAD2 y SMAD4 para potenciar sus actividades de unión al ADN. Esta interacción inhibe la transcripción de la IL-2 en células T.

Abstract from DBpedia / Wikipedia · CC BY-SA