Structure via PubChem · Public domain (PubChem)
topiroxostat
Sign in to saveAlso known as C13H8N6, 4-(5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl)pyridine-2-carbonitrile
Topiroxostat (INN; trade names Topiloric, Uriadec) is a drug for the treatment of gout and hyperuricemia. It was approved for use in Japan in June 2013.
In the Vinony graph
Vinony's link graph records 204 inbound references to topiroxostat, and connects out to adenosine receptor, inositol and oxypurinol.
It sits within the topics Chemical pages without DrugBank identifier, Drugs not assigned an ATC code and Drugs with non-standard legal status.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C13H8N6
- Molecular weight
- 248.24 g/mol
- IUPAC name
- 4-(5-pyridin-4-yl-1H-1,2,4-triazol-3-yl)pyridine-2-carbonitrile
- SMILES
- C1=CN=CC=C1C2=NC(=NN2)C3=CC(=NC=C3)C#N
- InChIKey
- UBVZQGOVTLIHLH-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 91.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- diabetic nephropathy, hyperuricemia
via ChEMBL · EBI
Research
139 papers- Topiroxostat-A Safer Uricostatic Drug with Enhanced Renal Protection: A Narrative Review.The Journal of the Association of Physicians of India · 2024
- Topiroxostat ameliorates oxidative stress and inflammation in sepsis-induced lung injury.Zeitschrift fur Naturforschung. C, Journal of biosciences · 2020
- Topiroxostat improves glomerulosclerosis in type 2 diabetic Nagoya Shibata Yasuda mice with early diabetic kidney disease.European journal of pharmacology · 2024
- Protective Effect of Topiroxostat on Myocardial Injury Induced by Lipopolysaccharide.The Journal of surgical research · 2022
- Topiroxostat versus allopurinol in patients with chronic heart failure complicated by hyperuricemia: A prospective, randomized, open-label, blinded-end-point clinical trial.PloS one · 2022
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 248.081
Show 3 more facts
- chemical formula
- C₁₃H₈N₆
- canonical SMILES
- C1=CN=CC=C1C2=NC(=NN2)C3=CC(=NC=C3)C#N
- subject has role
- xanthine oxidase inhibitor
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Topiroxostat (INN; trade names Topiloric, Uriadec) is a drug for the treatment of gout and hyperuricemia. It was approved for use in Japan in June 2013.
Topiroxostat is a xanthine oxidase inhibitor which reduces serum urate levels.
Excerpted from Wikipedia’s “topiroxostat” article, available under the CC BY-SA 4.0 licence.