Trametinib, sold under the brand name Mekinist among others, is an anticancer medication used for the treatment of melanoma and glioma. It is a MEK inhibitor drug with anti-cancer activity. It inhibits MEK1 and MEK2. It is taken by mouth.
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{{Infobox drug | image = Trametinib.svg | image_class = skin-invert-image | alt = | caption =
| pronounce = | tradename = Mekinist, Spexotras | Drugs.com = | MedlinePlus = a613040 | DailyMedID = Trametinib | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = L01 | ATC_suffix = EE01
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