ivosidenib

Ivosidenib, sold under the brand name Tibsovo, is an anti-cancer medication for the treatment of acute myeloid leukemia (AML) and cholangiocarcinoma. It is a small molecule inhibitor of isocitrate dehydrogenase-1 (IDH1), which is mutated in several forms of cancer. Ivosidenib is an isocitrate dehydrogenase-1 inhibitor that works by decreasing abnormal production of the oncometabolite 2-hydroxyglutarate (2-HG), leading to differentiation of malignant cells.

In the Vinony graph

Vinony's link graph records 280 inbound references to ivosidenib, and connects out to antineoplastic, cancer and public domain.

It is catalogued under topics including Antineoplastic drugs, CYP3A4 inducers and Disubstituted pyridines.

Vinony links it to 7 Wikipedia language editions.

Chemical data

Formula: C28H22ClF3N6O3
Molecular weight: 583 g/mol
IUPAC name: (2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxopyrrolidine-2-carboxamide
SMILES: C1CC(=O)N([C@@H]1C(=O)N(C2=CC(=CN=C2)F)[C@@H](C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N
InChIKey: WIJZXSAJMHAVGX-DHLKQENFSA-N
XLogP: 3.4
Polar surface area: 119 Å²
H-bond donors: 1
H-bond acceptors: 9
Formal charge: 0

via PubChem

Wikidata facts

Subclass of: chemical compound
Mass: 582.139400904
Has use: medication

Show 4 more facts

canonical SMILES: C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N
chemical formula: C₂₈H₂₂ClF₃N₆O₃
isomeric SMILES: C1CC(=O)N([C@@H]1C(=O)N(C2=CC(=CN=C2)F)[C@@H](C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N
legal status (medicine): boxed warning

Sources (4)

via Wikidata · CC0

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