trastuzumab
Sign in to saveAlso known as R-597, 4D5v8, Anti HER2, Ig gamma-1 chain C region
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication. Trastuzumab is given by slow injection into a vein and injection just under the skin.
Research
17,822 papers- Trastuzumab Deruxtecan: First Approval.Drugs · 2020
- Trastuzumab-Induced Cardiomyopathy.Cardiology clinics · 2019
- Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer.Cancer communications (London, England) · 2023
- Trastuzumab administration during pregnancy: an update.BMC cancer · 2021
- Trastuzumab Cardiotoxicity: Mechanism and Management.Biological & pharmaceutical bulletin · 2025
via PubMed
~20 min read
Encyclopedic overview
14 sectionsContents
- Medical uses
- Duration of treatment
- Adverse effects
- Mechanism of action
- Predicting response
- Resistance
- History
- Society and culture
- Economics
- Biosimilars
- Related conjugates
- References
- Further reading
- External links
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication. Trastuzumab is given by slow injection into a vein and injection just under the skin.
Common side effects include fever, infection, cough, headache, trouble sleeping, and rash. Other severe side effects include heart failure, allergic reactions, and lung disease. Use during pregnancy may harm the baby. Trastuzumab works by binding to the HER2 receptor and slowing down cell replication.
Excerpted from Wikipedia’s “trastuzumab” article, available under the CC BY-SA 4.0 licence.