trastuzumab
Sign in to saveAlso known as R-597, 4D5v8, Anti HER2, Ig gamma-1 chain C region
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication. Trastuzumab is given by slow injection into a vein and injection just under the skin.
In the Vinony graph
Within Vinony's link graph, trastuzumab is referenced by 739 other articles, and connects out to Erb-b2 receptor tyrosine kinase 2, heart failure and intravenous infusion and defusion.
Vinony files it under Chemicals that do not have a ChemSpider ID assigned, Cleanup tagged articles with a reason field from October 2016 and Drugboxes which contain changes to verified fields.
Its subject is documented across 32 Wikipedia language editions.
Chemical data
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Antibody
- First approval
- 1998
- Admin. routes
- parenteral
- Indications
- adenocarcinoma, breast carcinoma, carcinoma, neoplasm
via ChEMBL · EBI
Research
17,822 papers- Trastuzumab Deruxtecan: First Approval.Drugs · 2020
- Trastuzumab-Induced Cardiomyopathy.Cardiology clinics · 2019
- Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer.Cancer communications (London, England) · 2023
- Trastuzumab administration during pregnancy: an update.BMC cancer · 2021
- Trastuzumab Cardiotoxicity: Mechanism and Management.Biological & pharmaceutical bulletin · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has use
- medication
Show 5 more facts
- subject has role
- monoclonal antibody
- World Health Organisation international non-proprietary name
- trastuzumab
- Commons category
- Trastuzumab
- has characteristic
- biopharmaceutical
- legal status (medicine)
- boxed warning
via Wikidata · CC0
~20 min read
Encyclopedic overview
14 sectionsContents
- Medical uses
- Duration of treatment
- Adverse effects
- Mechanism of action
- Predicting response
- Resistance
- History
- Society and culture
- Economics
- Biosimilars
- Related conjugates
- References
- Further reading
- External links
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication. Trastuzumab is given by slow injection into a vein and injection just under the skin.
Common side effects include fever, infection, cough, headache, trouble sleeping, and rash. Other severe side effects include heart failure, allergic reactions, and lung disease. Use during pregnancy may harm the baby. Trastuzumab works by binding to the HER2 receptor and slowing down cell replication.
Excerpted from Wikipedia’s “trastuzumab” article, available under the CC BY-SA 4.0 licence.