tribenoside

Also known as GLY401, Tribenosido, Tribenosidum, TBGF

Tribenoside (Glyvenol) is a vasoprotective drug used to treat hemorrhoids. It has mild anti-inflammatory, analgesic, and wound healing properties. Tribenoside stimulates laminin α5 production and laminin-332 deposition to help repair the basement membrane during the wound healing process. It is a mixture of the α- and β-anomers.

Chemical data

Formula: C29H34O6
Molecular weight: 478.6 g/mol
IUPAC name: (3R,4R,5R)-5-[(1R)-1,2-bis(phenylmethoxy)ethyl]-2-ethoxy-4-phenylmethoxyoxolan-3-ol
SMILES: CCOC1[C@@H]([C@H]([C@H](O1)[C@@H](COCC2=CC=CC=C2)OCC3=CC=CC=C3)OCC4=CC=CC=C4)O
InChIKey: ULLNJSBQMBKOJH-VIVFLBMVSA-N
XLogP: 3.9
Polar surface area: 66.4 Å²
H-bond donors: 1
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: cardiovascular disease, hemorrhoid

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 478.236

Show 5 more facts

chemical formula: C₂₉H₃₄O₆
canonical SMILES: CCOC1C(C(C(O1)C(COCC2=CC=CC=C2)OCC3=CC=CC=C3)OCC4=CC=CC=C4)O
isomeric SMILES: CCOC1[C@@H]([C@H]([C@H](O1)[C@@H](COCC2=CC=CC=C2)OCC3=CC=CC=C3)OCC4=CC=CC=C4)O
subject has role: non-steroidal anti-inflammatory drug
World Health Organisation international non-proprietary name: tribenoside

Sources (3)

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Encyclopedic overview

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Contents

References

Tribenoside has been shown to induce drug hypersensitivity syndrome in association with CMV reactivation.

Excerpted from Wikipedia’s “tribenoside” article, available under the CC BY-SA 4.0 licence.

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