Structure via PubChem · Public domain (PubChem)
Chemical data
- Formula
- C20H24O6
- Molecular weight
- 360.4 g/mol
- IUPAC name
- (1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one
- SMILES
- CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C
- InChIKey
- DFBIRQPKNDILPW-CIVMWXNOSA-N
- XLogP
- 0.2
- Polar surface area
- 84.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- infection, HIV infection, Autosomal dominant polycystic kidney disease, non-small cell lung carcinoma
via ChEMBL · EBI
Research
2,094 papers- Triptolide-targeted delivery methods.European journal of medicinal chemistry · 2019
- Triptolide prevents LPS-induced skeletal muscle atrophy via inhibiting NF-κB/TNF-α and regulating protein synthesis/degradation pathway.British journal of pharmacology · 2021
- Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer.Cellular & molecular biology letters · 2024
- Triptolide, A Potential Autophagy Modulator.Chinese journal of integrative medicine · 2019
- Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives.Theranostics · 2021
via PubMed
Wikidata facts
- Mass
- 360.157
Show 6 more facts
- chemical formula
- C₂₀H₂₄O₆
- canonical SMILES
- CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C
- isomeric SMILES
- CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C
- subject has role
- alkylating antineoplastic agent
- Commons category
- Triptolide
- found in taxon
- Tripterygium wilfordii
via Wikidata · CC0
Article · Español
Triptolide es un epóxido diterpenoide producido por la vid del dios del trueno, Tripterygium wilfordii. Tiene actividades in vitro e in vivo contra modelos de ratón de enfermedad renal poliquística y cáncer pancreático, pero sus propiedades físicas y toxicidad severa limitan su potencial terapéutico. En consecuencia, un profármaco sintético soluble en agua, Minnelide, se está estudiando clínicamente en su lugar.
Abstract from DBpedia / Wikipedia · CC BY-SA