tropomyosin
Sign in to saveAlso known as IPR000533
Tropomyosin is a two-stranded alpha-helical, coiled coil protein found in many animal and fungal cells. In animals, it is an important component of the muscular system which works in conjunction with troponin to regulate muscle contraction. It is present in smooth and striated muscle tissues, which can be found in various organs and body systems, including the heart, blood vessels, respiratory system, and digestive system. In fungi, tropomyosin is found in cell walls and helps maintain the structural integrity of cells.
Key facts
- Protein family.image
- 1C1G Tropomyosin crystal.png
- Protein family.InterPro
- IPR000533
- Protein family.Symbol
- Tropomyosin
- Protein family.Pfam
- PF00261
- Protein family.PRINTS
- PR00194
- Protein family.PROSITE
- PDOC00290
- Protein family.SCOP
- 2tma
via Wikipedia infobox
Research
10,311 papers- Actin-tropomyosin distribution in non-muscle cells.Journal of muscle research and cell motility · 2020
- Tropomyosin: function follows structure.Advances in experimental medicine and biology · 2008
- Tropomyosin: A panallergen that causes a worldwide allergic problem.Allergy and asthma proceedings · 2021
- Tropomyosin: an invertebrate pan-allergen.International archives of allergy and immunology · 1999
- Tropomyosin Structure, Function, and Interactions: A Dynamic Regulator.Sub-cellular biochemistry · 2017
via PubMed
~28 min read
Encyclopedic overview
23 sectionsContents
- Tropomyosin and the actin skeleton
- Isoforms and evolution
- Genes and isoforms (isoform complexity)
- Splicing
- Evolution of isoform generation
- Spatial sorting of tropomyosin isoforms
- Regulation of sorting
- Mechanism of sorting
- Isoforms are not functionally redundant
- Specific roles and functions
- Influencing binding of actin binding proteins to actin filaments
- Function in skeletal muscle contraction
- Regulation of contraction in smooth muscle
- Role in cytoskeleton function
- Role in diseases
- Cancer
- Autoimmunity
- Muscle diseases
- Allergies
- Tools and technologies to study tropomyosins
- Antibodies
- References
- External links
Tropomyosin is a two-stranded alpha-helical, coiled coil protein found in many animal and fungal cells. In animals, it is an important component of the muscular system which works in conjunction with troponin to regulate muscle contraction. It is present in smooth and striated muscle tissues, which can be found in various organs and body systems, including the heart, blood vessels, respiratory system, and digestive system. In fungi, tropomyosin is found in cell walls and helps maintain the structural integrity of cells.
Tropomyosin is also found in other eukaryotes, but not in plants. Overall, tropomyosin is an important protein that plays a vital role in the proper functioning of many different organisms.
Excerpted from Wikipedia’s “tropomyosin” article, available under the CC BY-SA 4.0 licence.