VPREB3
Sign in to saveAlso known as 8HS20, N27C7-2, pre-B lymphocyte 3, V-set pre-B cell surrogate light chain 3
Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.
In the Vinony graph
Vinony's link graph records 3 inbound references to VPREB3, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 22.
Vinony links it to 6 Wikipedia language editions.
Gene data
VPREB3- Name
- V-set pre-B cell surrogate light chain 3
- Type
- protein-coding
- Position
- 23,752,741–23,754,454 (−)
- Aliases
- 8HS20, N27C7-2
- Ensembl
- ENSG00000128218
- RefSeq RNA
- NM_013378.3
- RefSeq protein
- NP_037510.1
The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015].
Gene Ontology
Biological process
via MyGene.info
Gene · Ensembl
V-set pre-B cell surrogate light chain 3
- Symbol
- VPREB3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:23,752,741-23,754,454
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 7598
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/29802
- genomic end
- 23754425
- genomic start
- 24094930
- chromosome
- human chromosome 22
- cytogenetic location
- 22q11.23|22q11
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.
The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-lymphocyte differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells. In humans, besides the bone marrow and secondary lymphoid tissues such as the tonsils, the VPREB3 protein is also present in Purkinje cells of the cerebellum and in the zona glomerulosa of the adrenal.
Excerpted from Wikipedia’s “VPREB3” article, available under the CC BY-SA 4.0 licence.