VPREB1
Sign in to saveAlso known as IGI, IGVPB, VPREB, CD179a, pre-B lymphocyte 1, V-set pre-B cell surrogate light chain 1
Immunoglobulin iota chain is a protein that in humans is encoded by the VPREB1 gene. VPREB1 has also recently been designated CD179A (cluster of differentiation 179A).
Gene data
VPREB1- Name
- V-set pre-B cell surrogate light chain 1
- Type
- protein-coding
- Aliases
- CD179a, IGI, IGVPB, VPREB
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
via MyGene.info
Wikidata facts
- Image
- Protein VPREB1 PDB 2h32.png
Show 5 more facts
- HomoloGene ID
- 84741
- exact match
- identifiers.org/ncbigene/7441
- genomic end
- 22599927
- genomic start
- 22244780
- cytogenetic location
- 22q11.22
Sources (4)
via Wikidata · CC0
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Article
4 sectionsContents
- Function
- References
- Further reading
- External links
Immunoglobulin iota chain is a protein that in humans is encoded by the VPREB1 gene. VPREB1 has also recently been designated CD179A (cluster of differentiation 179A).
== Function ==