WT1 transcription factor

Also known as Wilms tumor 1, WT33, Wilms tumor protein isoform Ex4a(+), WT1, Wilms tumor protein, WT1 protein, WT1 proteins, WT1 protein, human

mammalian protein found in Homo sapiens

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Within Vinony's link graph, WT1 transcription factor is referenced by 1,010 other articles, and connects out to PubMed, tumor suppressor gene and nephroblastoma.

It is catalogued under topics including Genes on human chromosome 11 and Protein pages needing a picture.

Its subject is documented across 9 Wikipedia language editions.

Protein · UniProt

Wilms tumor protein

Gene: WT1
Organism: Homo sapiens (Human)
Length: 449 aa
Molecular mass: 49,188 Da
Evidence: 1: Evidence at protein level

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:17716689, PubMed:25258363, PubMed:7862533). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA an…

3D-structureAlternative initiationAlternative splicingChromosomal rearrangementCytoplasmDisease variantDNA-bindingIsopeptide bond

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Swiss-Prot (reviewed) · via UniProt