WT1 transcription factor

Protein · UniProt

Wilms tumor protein

Gene

WT1

Organism

Homo sapiens (Human)

Length

449 aa

Molecular mass

49,188 Da

Evidence

1: Evidence at protein level

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:17716689, PubMed:25258363, PubMed:7862533). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA an…

• WT1--more than a transcription factor?Trends in biochemical sciences · 1998
• WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020
• The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1993
• Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury.Kidney international · 2024
• Wt1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium.Development (Cambridge, England) · 2022

via PubMed

• PHASE1/PHASE2RECRUITING
  Lurbinectedin in FET-Fused TumorsChildren's Hospital of Philadelphia · NCT05918640

via ClinicalTrials.gov

Wikidata facts

via Wikidata · CC0