ZHX3

Also known as TIX1, zinc fingers and homeoboxes 3

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.

Gene data

ZHX3

Name: zinc fingers and homeoboxes 3
Type: protein-coding
Position: 41,178,448–41,317,731 (−)
Aliases: TIX1
Ensembl: ENSG00000174306
RefSeq RNA: NM_001384315.1, NM_001384316.1, NM_001384317.1, NM_001384318.1, NM_001384319.1
RefSeq protein: NP_001371244.1, NP_001371245.1, NP_001371246.1, NP_001371247.1, NP_001371248.1

This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II positive regulation of osteoblast differentiation negative regulation of DNA-templated transcription

Molecular function

DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding protein homodimerization activity protein heterodimerization activity

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm

via MyGene.info

Gene · Ensembl

zinc fingers and homeoboxes 3

Symbol: ZHX3
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:41,178,448-41,317,783
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein ZHX3 PDB 2da5.png

Show 5 more facts

HomoloGene ID: 9000
exact match: identifiers.org/ncbigene/23051
genomic end: 39946312
genomic start: 39807088
cytogenetic location: 20q12

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Further reading

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.

This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded Protein contains two C2H2-type zinc fingers and five Homeodomains and forms a Dimer with itself or with Zinc fingers and homeoboxes family member 1. In the Nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor.fx