EntityQ220426· pop 27· linked from 945 articles

zopiclone

Key facts

Drug.Watchedfields: changed
Drug.verifiedrevid: 458773669
Drug.IUPAC_name: (RS)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
Drug.image: Zopiclone structure.svg
Drug.image_class: skin-invert-image
Drug.width: 200
Drug.caption: Above: molecular structure of zopiclone Below: 3D representation of the (S)-zopiclone molecule
Drug.image2: Zopiclone 3D.png
Drug.image_class2: bg-transparent
Drug.width2: 230
Drug.tradename: Imovane, Zimovane, Dopareel, others
Drug.pregnancy_AU: C
Drug.legal_AU: S4
Drug.dependency_liability: High
Drug.routes_of_administration: Oral tablets, 3.75 mg or 7.5mg (UK), 5 mg, 7.5 mg, or 10 mg (JP)
Drug.bioavailability: 75–80%
Drug.protein_bound: 52–59%
Drug.metabolism: Hepatic through CYP3A4 and CYP2E1

via Wikipedia infobox

Article

18 sections

Contents

Medical uses
Specific populations
Elderly
Liver disease
Adverse reactions
Contraindications
EEG and sleep
Overdose
Interactions
Pharmacology
Pharmacokinetics
Chemistry
Detection in biological fluids
History
Society and culture
Recreational use
References
External links

Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine, specifically a cyclopyrrolone, used to treat insomnia. While molecularly distinct from benzodiazepine drugs, Zopiclone's mechanism of action is similar; it increases the normal transmission of the neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system, via positive allosteric modulation at GABAA neurons.

Zopiclone is considered a sedative and CNS depressant. After prolonged use, the body can become accustomed to the effects of zopiclone. When the dose is then reduced or the drug is abruptly stopped, withdrawal symptoms may result. These can include a range of symptoms similar to those of benzodiazepine withdrawal. Although withdrawal symptoms from therapeutic doses of zopiclone and its isomers (i.e., eszopiclone) do not typically present with convulsions and are therefore not considered life-threatening, patients may experience such significant agitation or anxiety that they seek emergency medical attention.