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Structure via PubChem · Public domain (PubChem)
5-APDI
Sign in to saveAlso known as indanylaminopropane, 5-(2-aminopropyl)-2,3-dihydro-1H-indene
'5-(2-Aminopropyl)-2,3-dihydro-1H-indene (5-APDI), also known as indanylaminopropane (IAP), 2-aminopropylindane (2-API), indanametamine, and, incorrectly, as indanylamphetamine', is an entactogen and psychedelic drug of the amphetamine family. It has been sold by online vendors through the Internet and has been encountered as a designer drug since 2003, but its popularity and availability has diminished in recent years.
Chemical data
- Formula
- C12H17N
- Molecular weight
- 175.27 g/mol
- IUPAC name
- 1-(2,3-dihydro-1H-inden-5-yl)propan-2-amine
- SMILES
- CC(CC1=CC2=C(CCC2)C=C1)N
- InChIKey
- QYVNZHBQYJRLEX-UHFFFAOYSA-N
- XLogP
- 2.5
- Polar surface area
- 26 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 175.136
Show 3 more facts
- chemical formula
- C₁₂H₁₇N
- canonical SMILES
- CC(CC1=CC2=C(CCC2)C=C1)N
- Commons category
- Indanylaminopropane
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
'5-(2-Aminopropyl)-2,3-dihydro-1H-indene (5-APDI), also known as indanylaminopropane (IAP), 2-aminopropylindane (2-API), indanametamine, and, incorrectly, as indanylamphetamine', is an entactogen and psychedelic drug of the amphetamine family. It has been sold by online vendors through the Internet and has been encountered as a designer drug since 2003, but its popularity and availability has diminished in recent years.
5-APDI appears to act as a potent and weakly selective serotonin releasing agent (SSRA) with IC50 values of 82 nM, 1,848 nM, and 849 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine, respectively. It fully substitutes for MBDB but not amphetamine in trained animals, though it does produce disruption for the latter at high doses.
Excerpted from Wikipedia’s “5-APDI” article, available under the CC BY-SA 4.0 licence.